Athletes and bodybuilders are constantly seeking improvements through supplementation such as creatine monohydrate. Derived from amino acids, creatine increases phosphocreatine (CP) and adenosine triphosphate (ATP) energy stores; therefore, the potential training workloads will increase. Current research will provide information in regards to the beneficial and safe impact creatine supplementation exhibits on human muscle. The purpose of this study and presentation is to demonstrate that oral intake of clinical doses of creatine monohydrate will result in skeletal muscle hypertrophy and strength when combined with resistance training. Also, creatine supplementation is associated with a reduction of body fat. A meta analysis of research was performed and results will be discussed.