Critical limb ischemia involves the blockage of circulation to the extremities and may result in chronic wounds. Wound healing status can be predicted by Transcutaneous Oximetry (TcPO2) and Skin Perfusion Pressure (SPP). TcPO2 has been established to provide a direct measurement of the level of oxygenation. SPP involves the noninvasive use of a laser Doppler to assess microcirculation. Research suggests that SPP and TcPO2 provide valuable wound healing data; however, the emerging use of SPP warrants examination in its validity. Therefore, the purpose of this literature review is to determine the correlation between TcPO2 and SPP. The current evidence supports a positive correlation between SPP and TcPO2; this suggests that SPP is a valid measurement. However, further research is warranted in order to verify these claims.